Virus Protease
Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.
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Virus Protease Related Products (398)
Related Products (398)
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Antibodies (1)
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Carmofur (Standard)
0 ImagesSynonyms: HCFU (Standard)Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).
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CHIKV nsP2 protease-IN-3
0 ImagesCat. No.: HY-175279CHIKV nsP2 protease-IN-3 (Compound 5) is an irreversible covalent inhibitor targeting the nonstructural protein 2 (nsP2) cysteine protease of chikungunya virus (CHIKV) (IC50=0.5 μM). CHIKV nsP2 protease-IN-3 inhibits viral RNA replication. CHIKV nsP2 protease-IN-3 is promising for research of alphaviruses.
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SIMR-2418
0 ImagesCat. No.: HY-180369CAS No.: 2694123-92-5
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HCV-796 analog
0 ImagesCat. No.: HY-10467CAS No.: 691852-36-5HCV-796 analog is a potent NS5B inhibitor that binds to the palm II site. HCV-796 analog is promising for research of hepatitis C (HCV) infections.
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9-Aminominocycline
0 ImagesCat. No.: HY-168917CAS No.: 149934-19-0Synonyms: 9-AMN9-Aminominocycline (9-AMN) is the inhibitor for SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC50 of 4.55 µM and 4.15 µM. 9-Aminominocycline inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC50 of 1.04 µM and 2.35 µM.
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(±)-Tuaimenal A
0 ImagesCat. No.: HY-174251CAS No.: 2767310-50-7
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Viroxime
0 ImagesCat. No.: HY-106312CAS No.: 63198-97-0Synonyms: LY 122771-72Viroxime is an antiviral agent.
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AG-1859
0 ImagesCat. No.: HY-106247CAS No.: 478410-84-3
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SARS-CoV-2 Mpro-IN-52
0 ImagesCat. No.: HY-180458CAS No.: 3035282-25-5SARS-CoV-2 Mpro-IN-52 (compound 47) is a potent SARS-CoV-2 main protease (MPro) inhibitor (EC50 = 0.0099 µM) with antiviral activity. SARS-CoV-2 Mpro-IN-52 exhibits potent and broad-spectrum activity against MERS, OC43, 229E with EC50s of 0.00961, 0.138, and 0.117 µM. SARS-CoV-2 Mpro-IN-52 can be used for COVID-19 research.
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Rupintrivir (Standard)
0 ImagesCat. No.: HY-106161RCAS No.: 223537-30-2Synonyms: AG7088 (Standard)Rupintrivir (Standard) is the analytical standard of Rupintrivir (HY-106161). This product is intended for research and analytical applications. Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.
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Mergocriptine
0 ImagesCat. No.: HY-136967CAS No.: 81968-16-3Synonyms: CBM36-733Mergocriptine (CBM36-733) is a dopamine receptor agonist and SARS-CoV-2 Mpro ligand. Mergocriptine regulates ambulatory activity.
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4E2RCat (Standard)
0 ImagesCat. No.: HY-100733RCAS No.: 432499-63-3
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Koenine
0 ImagesCat. No.: HY-N15268CAS No.: 28200-63-7Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (Mpro), which can be used in the research of anti-novel coronavirus drugs.
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ZHAWOC25153
0 ImagesCat. No.: HY-170504ZHAWOC25153 (Compound 17o) is a SARS-CoV-2 papain-like cysteine protease (PLpro) inhibitor, with an IC50 of 7 μM. ZHAWOC25153 exhibits antiviral activity and can be used in research within the field of anti-infection.
